发明名称 |
METHODS AND COMPOSITIONS FOR NON-VIRAL GENE THERAPY FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES |
摘要 |
The present invention relates to non-viral gene therapy methods and compositions for treatment of hyperproliferative disease in humans. More specifically, the invention is directed, in one embodiment, to lipid formulations which form stable liposome structures, capable of efficient <i>in vivo</i> nucleic acid transfer. In other embodiments, methods and compositions are directed to liposome transfer of anti-proliferative nucleic acids, wherein the transfer of the nucleic acids is cell specific <i>via</i> cell specific targeting moieties. The present invention, thus provides non-viral, liposome compositions and methods of gene transfer particularly useful for targeting and treating hyperproliferative disease.
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申请公布号 |
WO0071096(A3) |
申请公布日期 |
2001.05.03 |
申请号 |
WO2000US14350 |
申请日期 |
2000.05.24 |
申请人 |
INTROGEN THERAPEUTICS, INC.;BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;RAMESH, RAJAGOPAL;ROTH, JACK, A.;SAEKI, TOMOYUKI;WILSON, DEBORAH |
发明人 |
RAMESH, RAJAGOPAL;ROTH, JACK, A.;SAEKI, TOMOYUKI;WILSON, DEBORAH |
分类号 |
A61K9/127;A61K38/17;A61K48/00;C12N15/88;(IPC1-7):A61K9/127;A61K31/708;A61P35/00 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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