发明名称 |
PEPTIDES AND THEIR UTILITY IN MODULATION OF BEHAVIOR OF CELLS EXPRESSING alpha 3 beta 1 INTEGRINS |
摘要 |
The present invention relates to a peptide comprising the sequence R1-X1-X2-X3-X4-R2, wherein X1 is selected from the group consisting of N, Q, D and S; X2 is selected from the group consisting of V, I and L; X3 is selected from the group consisting of R and K; and X4 is selected from the group consisting of V, I, L and F; R1 is a hydrogen or a peptide of 1 to 6 amino acids, and acyl or an aryl group; and R2 is a peptide of 1 to 3 amino acids, a hydroxide or an amide. The invention also relates to partial or full retro-inverso peptides comprising the above sequences. The invention also relates to peptide-substrate combination comprising a substrate suitable for cell growth and the peptide of the invention, and to a vascular graft and an artificial blood vessel comprising the peptide-substrate combination. The invention also relates to a pharmaceutical composition and a peptide conjugate comprising the peptide of the invention. The invention also relates to a method of inhibiting adhesion of a cell expressing alpha 3 beta 1 integrin to an extracellular matrix, inhibiting alpha 3 beta 1-integrin-mediated cell motility, inhibiting alpha 3 beta 1-integrin mediated cell proliferation, promoting alpha 3 beta 1-integrin mediated cell proliferation and inhibiting angiogenesis utilizing the peptides of the invention.
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申请公布号 |
WO0105812(A3) |
申请公布日期 |
2001.05.03 |
申请号 |
WO2000US18986 |
申请日期 |
2000.07.12 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES;ROBERTS, DAVID, D.;KRUTZSCH, HENRY, C. |
发明人 |
ROBERTS, DAVID, D.;KRUTZSCH, HENRY, C. |
分类号 |
A61K38/00;C07K14/78;(IPC1-7):C07K14/78;A61F2/06;A61K38/39;A61P35/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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