IMIDAZOL-4-YLMETHANOLS USE AS INHIBITORS OF STEROID C17-20 LYASE

摘要

The present invention provides a compound represented by formula (I), wherein R is a hydrogen atom or a protecting group, R<1> is a lower alkyl group or a cyclic alkyl group, R<2> is a group represented by formula (1), (wherein a ring A<1> is a 5- or 6-membered ring containing an oxygen atom optionally having substituents, and a ring A<2> and a ring A<3> may have substituents), a group represented by formula (2), (wherein the ring B<1> is a 5- or 6-membered ring containing an oxygen atom optionally having substituents and a ring B<2> and a ring B<3> may have substituents) or a group of formula (3), (wherein each of R<3> and R<5> is a hydrogen atom, a lower alkyl group optionally having substituents, a hydroxyl group optionally having substituents, a thiol group optionally having substituents, an amino group optionally having substituents, an acyl group or a halogen atom, R<4> is an aromatic hydrocarbon group optionally having substituents, a heterocyclic group optionally having substituents or a carbamoyl group optionally having substituents, R<6> is an optionally halogenated lower alkyl group and n is an integer of 0 to 3), or a salt thereof, which has an inhibitory activity of steroid C17-20-lyase and are useful for preventing and treating a mammal suffering from, for example, primary tumor, its metastasis and recurrence thereof, and various symptoms accompanied with these cancer, various diseases such as prostatic hypertrophy, virilism, hirsutism, male pattern alopecia, precocious puberty, endometriosis, uterus myoma, mastopathy, polycystic ovary syndrome, etc.