| 摘要 |
<p>The present invention relates to a preparing method of α-ketocarboxylic acid derivatives, more specifically to a preparing method of α-ketocarboxylic acid derivatives, expressed by Formula (1) and widely used as major source material for the synthesis of agrochemicals and medicines, by reacting α-hydroxycarboxylic acid derivatives with hypobromous acid (HOBr). In Formula (1), R1 represents hydrogen atom, C1∩C10alkyl, C1∩C10haloalkyl, C1∩C10alkoxyalkyl, C3∩C6 cycloalkyl or aryl, wherein the said aryl is benzene, naphthalene, pyridine or thiophene with more than one functional groups selected from hydrogen atom, hydroxy, halogen atom, C1∩C3alkyl, -(CH2)mL, C1∩C3alkoxy, phenoxy and nitro group, wherein the said L is halogen atom, alkylsulphonyloxy, benzenesulfonyloxy or toluenesulfonyl oxy group, and the said m is the integer number of 1 or 2; R2 represents hydrogen atom or C1∩C6alkyl; and n represents 0 or integer number of 1∩10.</p> |
