发明名称 |
HUMAN HOMOLOGUE OF YEAST HELICASE AND USES THEREOF |
摘要 |
The present invention provides a nucleic acid and amino acid sequence of a human Pif-1 type helicase. The invention also provides methods of screening for compounds that modulate the activity of human Pif-1 type helicase, as well as methods for affecting viability of a cell by contacting the cell with a human Pif-1 helicase modulator. Such contacting specifically increases or decreases the specific activity of the human helicase in the cell, and may affect its viability, by affecting telomere length regulatory processes.
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申请公布号 |
WO0130986(A2) |
申请公布日期 |
2001.05.03 |
申请号 |
WO2000US28780 |
申请日期 |
2000.10.18 |
申请人 |
BRISTOL-MYERS SQUIBB CO.;WEINMANN, ROBERTO;YANG, WEN-PIN |
发明人 |
WEINMANN, ROBERTO;YANG, WEN-PIN |
分类号 |
C12N15/09;A61K38/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/00;C12N9/90;C12Q1/25;(IPC1-7):C12N9/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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