| 摘要 |
Preventives or remedies for arrhythmia which contain as the active ingredients cPLA2 inhibitors such as compounds represented by general formula (I), wherein R<1> represents optionally substituted aralkyl, etc.; Z represents -S-, etc.; X<1> represents -(CH2)s-N(R<18>)-CO- (wherein R<18> represents hydrogen, etc.; and s is an integer of 0 to 3), etc.; X<2> represents optionally substituted arylene, etc.; X<3> represents a single bond, etc.; A, B and E independently represent each oxygen or sulfur; D represents hydrogen, etc.; Y<1> represents -(CH2)mCO- (wherein m is an integer of 0 to 3), etc.; and Y<2> represents optionally substituted aryl, etc.
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