NON-ANAPHYLACTIC FORMS OF GRASS POLLEN PH1 P 6 ALLERGEN AND THEIR USE
摘要
The invention relates to a hypoallergenic immunogenic molecule derived from the Phl p 6 allergen, wherein the Phl p 6 molecule has an N-terminal and/or C- terminal deletion which makes the molecule at least substantially lack IgE binding capacity. The invention also relates to a hypoallergenic immunogenic combination of molecules derived from the Phl p 6 allergen, comprising: (i) a Phl p 6 molecule having an N-terminal deletion which makes the molecule at least substantially lack IgE binding capacity, and (ii) a Phl p 6 molecule having a C-terminal deletion which makes the molecule at least substantially lack IgE binding capacity, which two molecules together encompass the comple te sequence of Phl p 6. The invention further relates to the use of the hypoallergenic immunogenic molecule or molecule mixture in hyposensitization and diagnosis.
申请公布号
CA2387260(A1)
申请公布日期
2001.05.03
申请号
CA20002387260
申请日期
2000.10.24
申请人
PHARMACIA DIAGNOSTICS AB;VALENTA, RUDOLF
发明人
KRAFT, DIETRICH;VALENT, PETER;SPERR, WOLFGANG R.;PASTORE, ANNALISA;STUMMVOLL, SABINE;GROTE, MONIKA;GRONLUND, HANS;VANGELISTA, LUCA;VRTALA, SUSANNE;VALENTA, RUDOLF