| 摘要 |
Novel 3-Z-9-benzoyl-1,2,3,4-tetrahydrocarbazoles, wherein Z is CONR5R6, CONHOH, CN, or COCH2X, where X is chloro or bromo, having antimicrobial and/or anti-inflammatory activity are disclosed. Compounds wherein Z is CONR5R6 and CONHOH are prepared from the corresponding 3-carboxylic acids by conversion to the corresponding acid chlorides and subsequent reaction with the appropriate amines and hydroxylamine respectively; compounds where Z is CN are prepared by the dehydration of the corresponding compounds where Z is CONH2; and the compounds where Z is COCH2X are prepared by reacting hydrogen chloride or bromide with the corresponding compounds where Z is COCHN2 which in turn is prepared from the corresponding 3-carboxylic acid chloride by reaction with diazomethane.
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