发明名称 |
Long analgesic acting nalbuphine polyester derivative and method of use |
摘要 |
The nalbuphine polyester derivative is related to a novel long acting agent. The nalbuphine polyester derivative is R-[CO-NAL]n wherein n is an integer from 2-4 and, in which the R is selected from a saturated or nonsaturated, substituted or unsubstituted, aliphatic or aromatic group having 1 to 40 carbon atoms. The process for producing the derivative includes esterifying nalbuphine with a saturated or unsaturated fatty acid or a halogen compound of the fatty acid with an acid anhydride. A pharmaceutical composition contains the derivative and a pharmaceutically acceptable carrier, which can be administered to an animal or person for treating pain.
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申请公布号 |
US6225321(B1) |
申请公布日期 |
2001.05.01 |
申请号 |
US19970869917 |
申请日期 |
1997.06.05 |
申请人 |
HU OLIVER YOA-PU;HO SHUNG-TAI;LEE FANGCHEN |
发明人 |
HU OLIVER YOA-PU;HO SHUNG-TAI;LEE FANGCHEN |
分类号 |
C07D498/04;(IPC1-7):C07D489/02;A61K31/485 |
主分类号 |
C07D498/04 |
代理机构 |
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