| 摘要 |
The invention relates to 9-halogen-(Z) prostane derivatives of formula Iin whichZ represents the radicalsHal represents a chlorine or fluorine atom in the alpha or beta position,R1 represents the radicalwith R2 meaning a hydrogen atom, an alkyl, cycloalkyl, aryl or heterocyclic radical or R1 represents the radicalwith R3 meaning an acid radical or the radical R2 andA represents a -CH2-CH2-, a trans-CH=CH or -C=C group,W represents a free or a functionally modifiedgroup, and the respective OH groups can be in the alpha or beta position,D and E together represent a direct bond orD represents a straight-chain alkylene group with 1-10 C atoms, a branched-chain alkylene group with 2-10 C atoms or an annular alkylene group with 3-10 C atoms, which optionally can be substituted by fluorine atoms, andE represents an oxygen or sulfur atom, a direct bond, a C=C bond or a -CR6=CR7 group, and R6 and R7 are different and mean a hydrogen atom, a chlorine atom or a C1-C4 alkyl group,R4 resents a free or functionally modified hydroxy group,R5 means a hydrogen atom, an alkyl, a halogen-substituted alkyl, a cycloalkyl or an optionally substituted aryl or a heterocyclic group, and if R2 means a hydrogen atom, its salts with physiologically compatible bases or its cyclodextrin chlathrates, process for their production and their pharmaceutical use.
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