发明名称 N-substituted 1-(lactone) isoquinolones for treating nervous disorders
摘要 The invention concerns compounds of general formula (I) wherein: Z represents a sulphur or oxygen atom, NH, N-alkyl or Nboc; group R', identical or different, represent each a hydrogen atom, a OCH3 group or a OCH2O group; group R'' represents a hydrogen or a CH3 group; group X represents a carbonyl, sulphonyl or CO2 group; and group R represents an alkyl, aryl, alkenyl or aralkyl group. The invention also concerns the preparation of said compounds, pharmaceutical compositions containing them and their use for stimulating gamma-amino-butyric acid activity and as medicine for treating nervous disorders.
申请公布号 AU7932000(A) 申请公布日期 2001.04.30
申请号 AU20000079320 申请日期 2000.10.20
申请人 CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);INNOVATIONSAGENTUR GMBH BU TECHNOLOGY MARKETING AUSTRIA (TECMA);UNIVERSITE DE BERN 发明人 ROBERT DODD;RODOLPHE RAZET;PIERRE JEAN-PAUL POTIER;WERNER SIEGHART;FRANTISEK JURSKY;ROMAN FURTMULLER;ERWIN SIGEL;URS THOMET
分类号 C07D491/056;A61K31/4725;A61K31/4741;A61P21/02;A61P25/00;A61P25/04;A61P25/08;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/28;A61P25/32;A61P43/00;C07D401/04;C07D405/04;C07D409/04 主分类号 C07D491/056
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