PROCESS FOR THE CHEMICAL SYNTHESIS OF OLIGONUCLEOTIDES AND CERTAIN NOVEL 5'-DANSYL ETHOXYCARBONYL OLIGONUCLEOTIDE INTERMEDIATES THEREOF

摘要

The use of a dansylethoxycarbonyl group as base-labile 5'-hydroxy protective group in the chemical synthesis of DNA and RNA and suitable synthetic processes. The ease of detection of the dansyl protective group and the ease of elimination from the sugar residue of the nucleotide without side reactions make it possible to synthesise oligonucleotides in minute amounts with high yields.