Regulating metabolism by modifying the level of trehalose-6-phosphate using TPP and TPS enzymes

摘要

Induction of a change in the intracellular availability of the saccharide trehalose-6-phosphate (T-6-P) induces modifications of the development and/or composition of cells, tissue and organs in vivo. These changes can be induced by using genetic recombination techniques to introduce or inhibit the enzymes trehalose phosphate synthase (TPS) that is capable of forming T-6-P and trehalose phosphate phosphatase (TPP) that degrades T-6-P into trehalose. The carbon flow through the glycolysis will be stimulated by a decrease in the intracellular level of T-6-P.