Bispyrido-cycloheptane compounds useful for inhibition of farnesyl protein transferase

摘要

Compounds of formula (1.0) or (2.0) wherein: A is alkyl, halo or hydrogen; B is methyl, halo or hydrogen; The dotted line is an optional double bond; R5, R6, R7 and R8 are independently selected from hydrogen, -CF3, -COR10, alkyl or aryl, wherein the alkyl and aryl may optionally be substituted with -OR10, -SR10. -S(O)tR11 (wherein t=0, 1 or 2), -NR10COOR11, -N(R10)2, -NO2, -COR10, -OCOR10, OCO2R11, -CO2R10, OPO3R10, or R5 is combined with R6 to represent =O or =S and/or R7 is combined with R8 to represent =O or =S; R10 represents hydrogen, alkyl, aryl or aralkyl; R11 represents alkyl or aryl; R is -C(O)R1, -C(O)OR1, -C(O)NR1R2, -S(O)SR1 AND -S(O)2NR1R2 wherein R1 and R2 are independently selected from hydrogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocycloalkyl; wherein the substituents are selected from one or more of alkyl, alkoxy, aralkyl, heteroarylalkyl, -NO2, alkyloxyalkyl, alkyloxyalkyloxyalkyl, =O, -OH, amino, substituted amino, nitro and halo; With the proviso that R1 is not H for -C(O)OR1 or -S(O)2R1. The compounds are useful for inhibiting farnesyl protein transferase function and therefore inhibiting the abnormal growth of cells and affecting an anti-allergic response.