摘要 |
A compound of formula (I) wherein: R1 is alkyl, alkenyl or cycloalkyl; R2 is alkyl or alkenyl; R3 is 1- or 2-indanyl, 1- or 2-(1,2,3,4-tetrahydronaphthalenyl), 9-fluorenyl, acenaphthyl or CHR4(CH2)nAr wherein n is 0 or 1, R4 is hydrogen or alkyl and Ar is quinolinyl, naphthalenyl, benzodioxolinyl optionally substituted by one or more halogen atoms, or phenyl optionally substituted by one or more substituent groups selected from halogen, alkyl, alkoxy and phenylsulfonylmethyl; W is H, CH2 OH, CO2 H, CO2alkyl, CH2NR5R6, CONR5R6, wherein R5 and R6 are independently hydrogen or alkyl, or W is pyridyl or phenyl, each of which may be optionally substituted by one or more substituent groups selected from halogen, hydroxyl, alkyl and alkoxy; X is a bond or alkylene; Y is S(O)p, C=C, CH=CH, CH2CH2 or CH2CH=CH; and p is 0, 1 or 2; or a pharmaceutically acceptable salt thereof, provided that X is not a bond when W is H, CH2 OH, CO2 H, CO2 C1-6 alkyl, CH2 NR5 R6 or CONR5 R6 and Y is sulfur.
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