摘要 |
<p>A method of producing an agglomerate of drug and solid binder selected from the group consisting of polyhydroxy aldehydes, polyhydroxy ketones and amino acids. The process involves producing individual agglomerate particles and then converting the convertible amorphous content of same, following agglomeration, by the application of, for example, moisture. Agglomerates capable of conversion as well as the finished agglomerates and oral and nasal dosing systems are described. The process produces agglomerates which have the desired hardness but which will also produce an acceptable fine particle fraction during dosing.</p> |