TETRAHYDROBENZINDOLONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT7 RECEPTOR ANTAGONISTS

摘要

The invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1 is halogen, C¿1-6?alkyl, hydroxy, C1-6alkoxy, C1-6alkylthio, C1-6alkylsulphinyl, C1-6alkylsulphonyl, amino, mono- or di-C1-6alkylamino, carboxy, carboxamido, hydroxyC1-6alkyl, mono- or di-C1-6alkylaminocarbonyl, sulphonamido, C1-6alkylsulphonylamino, aminoC1-6alkyl, mono- or di-C1-6alkylaminosulphonyl or C1-6alkoxycarbonyl; R?2¿ is hydrogen, C¿1-6?alkyl or arylC1-6alkyl; p is 0, 1, 2 or 3; R?3¿ is hydrogen or C¿1-6?alkyl; n is 2, 3, 4, 5 or 6; A is nitrogen, carbon or CH, ....., is a single bond when A is nitrogen or CH or ..... is a double bond when A is carbon; X is nitrogen or CH; Y is O, S, NH or N-C1-6alkyl, R?4¿ is halogen, C¿1-6?alkyl, cyano, CF3, C3-7cycloalkyl, C1-6alkoxy, hydroxy, amino, mono- or di-C1-6alkylamino, acylamino, nitro, C1-6alkoxycarbonyl, C1-6alkylthio, C1-6alkylsulphinyl, C1-6alkylsulphonyl, sulphamoyl, mono- and di-C1-6alkylsulphamoyl, carbamoyl, mono- and di-C1-6alkylcarbamoyl, C1-6alkylsulphonamido, arylsulphonamido, aryl, arylC1-6alkyl, arylC1-6alkoxy, aryloxy and arylthio; m is 0, 1, 2 or 3, having 5-HT7 antagonist activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders.