| 摘要 |
<p>The present invention relates to a process for preparing a chiral ester expressed in formula (100) by mixing and reacting: a ketone of formula (4); a ruthenium complex selected from the group consisting of compounds (1, 2 and 3) expressed in formula (1) to (3) to activate hydrogenation of said ketone to a racemic alcohol and racemization of said racemic alcohol; a lipase to acylate selectively one of enantiomers of said racemic alcohol; a hydride donor group to supply a hydride group to said ruthenium complex; and an acyl donor group to supply acyl group to said lipase. In formula (1) wherein Y1, Y2, Y3, Y4, Y5, Y6, Y7, Y8, Y9, Y10, Y11, and Y12 are independentlya hydrogen atom or C1-C5 alkyl group; and X is Br, Cl or I. In formula (2) wherein Y1, Y2, Y3, Y4, Y5, Y6 Y7, Y8, Y9, Y10, Y11, and Y12 are independently a hydrogen atom or C1-C5 alkyl group; and X is Br, Cl, or I. In formulae (3), (4), and (100) wherein R?1, R2, and R3¿ are, independently, optionally substituted alkyl, optionally substituted aryl or optionally substituted cyclyoalkyl group and R?1 and R2, R1 and R3, and R2 and R3¿ can be cyclized each other, where said substituent of alkyl, aryl and cycloalkyl is a hetero atom such as a halogen atom and a cyano group.</p> |
