发明名称 |
OLIGODEOXYNUCLEOTIDE AND ITS USE TO INDUCE AN IMMUNE RESPONSE |
摘要 |
The present invention provides a substantially pure or isolated oligodeoxynucleotide of at least about 10 nucleotides comprising a sequence represented by either the formula: 5' N1N2N3T-CpG-WN4N5N6 3' wherein the central CpG motif is unmethylated, W is A or T, and N1, N2, N3, N4, N5, and N6 are any ncleotides, or the formula: 5' RY-CpG-RY 3' wherein the central CpG motif is unmethylated, R is A or G, and Y is C or T, as well as an oligodeoxynucleotide delivery complex and a pharmacological composition comprising the present inventive oligodeoxynucleotide, and a method of inducing an immune response by administering the present inventive oligodeoxynucleotide to a host. |
申请公布号 |
WO0061151(A3) |
申请公布日期 |
2001.04.26 |
申请号 |
WO2000US09839 |
申请日期 |
2000.04.12 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;KLINMAN, DENNIS;ISHII, KEN;VERTHELYI, DANIELA |
发明人 |
KLINMAN, DENNIS;ISHII, KEN;VERTHELYI, DANIELA |
分类号 |
A61K31/7088;A61K39/008;A61K39/39;A61K45/06;C07H21/00;(IPC1-7):A61K31/70 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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