PROCESS FOR PRODUCING MICROORGANISM-ORIGIN TRANSGLUTAMINASE

摘要

A process for the secretory production of transglutaminase by using a microorganism. A process for the mass production of transglutaminase characterized by comprising culturing a bacterium belonging to the genus Streptomyces which has an expression plasmid carrying a transglutaminase gene originating in actinomycetes and the inherent (intact) promoter thereof, thus making the bacterium to secret protransglutaminase in the early stage to the medium stage of the culture, and then cutting off and removing the pro-structure with Streptomyces-origin protease, etc. in the latter stage of the culture to thereby give matured (active) transglutaminase.