发明名称 |
GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO |
摘要 |
GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have structure (I): wherein Ar, A, B, Q, R1, R2, R3a, R3b, R6, R7 and m are as defined herein, including stereoisomers, prodrugs and pharmaceutical acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
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申请公布号 |
CA2386942(A1) |
申请公布日期 |
2001.04.26 |
申请号 |
CA20002386942 |
申请日期 |
2000.10.16 |
申请人 |
NEUROCRINE BIOSCIENCES, INC. |
发明人 |
CHEN, CHEN;GAO, YINGHONG;GROSS, TIMOTHY D.;CONNORS, PATRICK J., JR.;ZHU, YUN-FEI;GUO, ZHIQIANG |
分类号 |
C07D471/04;A61K31/519;A61P1/00;A61P5/02;A61P5/04;A61P15/00;A61P17/00;A61P35/00;A61P43/00;C07D487/04;(IPC1-7):C07D487/04;A61K31/505 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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