A METHOD OF PRODUCING MICROBIAL TRANSGLUTAMINASE

摘要

A process for the secretory production of transglutaminase by using a microorganism. A process for the mass production of transglutaminase characterized by comprising culturing a bacterium belonging to the genus Streptomyces which has an expression plasmid carrying a transglutaminase gen e originating in actinomycetes and the inherent (intact) promoter thereof, thu s making the bacterium to secret protransglutaminase in the early stage to the medium stage of the culture, and then cutting off and removing the pro- structure with Streptomyces-origin protease, etc. in the latter stage of the culture to thereby give matured (active) transglutaminase.