SMALL MOLECULE MODULATORS OF NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS

摘要

Disclosed herein are non-endogenous, constitutively activated forms of the human 5-HT2A and human 5-HT2C receptors and uses of such receptors to screen candidate compounds. Further disclosed herein are candidate compounds identified by the screening method which act at the 5HT2A receptors. Yet further disclosed is a new class of compounds (I) which act at the 5HT2A receptors. This new class encompasses the candidate compounds. In Formula (A ) W is F, Cl, Br, I, C1-8 straight chain or branched alkyl, C3-8 cycloalkyl, C 4- 9 alkylcycloalkyl, or C2-8 alkenyl; X is O or S or NR2; Y is NR3R4, or (CH2)mR5, or O(CH2)nR6; m is an integer between 0 and 4, inclusive; n is an integer between 0 and 4, inclusive; Z is H, C1-8 straight chain or branched alkyl, C3-8 cycloalkyl, C4-9 alkylcycloalkyl, or C2-8 alkenyl; R1, R2, R3 an d R10 are as defined in the application.