发明名称 |
MELANOMA VACCINE AND METHODS OF MAKING AND USING SAME |
摘要 |
An immunotherapeutic vaccine providing antigen presenting cells that have been pulsed with a disrupted cell preparation which includes enucleated cytosol and cell membranes of cancer cells infected with a recombinant vaccinia virus encoding at least one immunostimulating molecule. In a preferred embodiment, the vaccine includes autologous dendritic/monocytic cells (DC/M) that present a mixture of antigens (present in the enucleated cytosol and cell membranes) from melanoma cell lines that have been infected with a recombinant vaccinia virus encoding IL-2. In another of the preferred embodiments, the enucleated cytosol and cell membranes are from melanoma cells harvested from the patient to be treated. A method of making the vaccine and methods of using the vaccine to stimulate an anti-cancer immune response and to treat a patient with a cancer are also described. |
申请公布号 |
WO0128583(A2) |
申请公布日期 |
2001.04.26 |
申请号 |
WO2000US28837 |
申请日期 |
2000.10.18 |
申请人 |
ST. VINCENT'S HOSPITAL AND MEDICAL CENTER OF NEW YORK |
发明人 |
WALLACK, MARC, K.;SIVANANDHAM, MUTHUKUMARAN |
分类号 |
A61K39/00;A61P35/00;A61P37/04 |
主分类号 |
A61K39/00 |
代理机构 |
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