发明名称 |
CHIMERIC IMMUNOGENIC COMPOSITIONS AND NUCLEIC ACIDS ENCODINGTHEM |
摘要 |
The invention provides chimeric nucleic acids encoding a chimeric polypeptid e, constructs for expressing these polypeptides both in vitro and in vivo, isolated chimeric polypeptides, pharmaceutical compositions and methods of making and using these compositions. These compositions and methods are particularly useful for stimulating or enhancing the immunogenicity of a selected antigen or stimulating or enhancing a cellular immune response specific for that antigen. The nucleic acid of the invention comprises a fir st polypeptide domain comprising a carboxy terminal fragment of a heat shock protein (HSP), an Flt-3 ligand (FL), a cytoplasmic translocation domain of a Pseudomonas exotoxin A (ETA dII), or a granulocyte-macrophage-colony stimulating factor (GM-CSF) sequence, and a second polypeptide domain comprising an antigenic polypeptide.
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申请公布号 |
CA2388045(A1) |
申请公布日期 |
2001.04.26 |
申请号 |
CA20002388045 |
申请日期 |
2000.10.20 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE |
发明人 |
HUNG, CHIEN-FU;WU, TZYY-CHOOU |
分类号 |
C12N15/09;A61K9/127;A61K38/00;A61K39/00;A61K39/39;A61K47/24;A61K48/00;A61P31/00;A61P35/00;A61P43/00;C07K14/025;C07K14/21;C07K14/35;C07K14/47;C07K14/475;C07K14/535;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/12;C12N15/27;C12N15/31;C12N15/37;(IPC1-7):C12N15/62;A61K39/04;A61K39/104;A61K39/12;A61K38/18;A61K38/19;C12N15/86 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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