PHARMACEUTICAL COMPOSITION FOR TREATMENT OF MUCOSAL EPITHELIAL ULCERATION AND/OR EROSION
摘要
A bioadhesive pharmaceutical composition for treatment of mucosal epithelial ulceration and/or erosions, said composition comprising: (i) a bioadhesive substance; (ii) a biologically active substance having MMP inhibitory activity; and (iii) an optional physiologically acceptable vehicle; said bioadhesive substance and optional physiologically acceptable vehicle being selected to release the biologically active substance in a therapeutic amount into the epithelia of the mucosa without affecting the normal flora thereof; use of the composition for the manufacture of a medicament for treating mucosal ulceration and/or erosion; a method of treating mucosal epithelial ulceration and/or erosion in a mammal; and a method of delivering a biologically active substance to the mucosa of a mammal for treatment of mucosal epithelial ulceration and/or erosion.
申请公布号
WO0128515(A1)
申请公布日期
2001.04.26
申请号
WO2000IS00013
申请日期
2000.10.22
申请人
LIF-HLAUP EHF. BIO-GELS PHARMACEUTICALS INC.;SKULASON, SKULI;HOLBROOK, W., PETER;KRISTMUNDSDOTTIR, THORDIS;GIZURARSON, SVEINBJORN
发明人
SKULASON, SKULI;HOLBROOK, W., PETER;KRISTMUNDSDOTTIR, THORDIS;GIZURARSON, SVEINBJORN