| 摘要 |
A pharmaceutical composition that inhibits or slows the infection or reinfection of animals, particularly mammals, by HIV or other retroviruses is disclosed. The composition comprises from about 10 mg to about 6000 mg of a (5-aryl- 1,2,4-thiadiazol)-3-yl thiourea derivative or (5-aryl- 1,2,4-thiadiazol)-3-yl urea derivative of formula: (I), wherein X is oxygen or sulfur, R is hydrogen or alkyl having from 1-3 carbons, n is 1-4, R is independently selected from the group consisting of hydrogen, alkyl having from 1 to 7 carbon atoms, chloro, bromo or fluoro, oxychloro, alkoxy having the formula -O(CH2)CH wherein y is from 1 to 6, or a pharmaceutically acceptable acid addition salt or prodrug thereof. The preferred compound is (5-phenyl-1,2,4-thiadazol-3-yl) thiourea. These pharmaceutical compositions maa also further contain other antiviral adjunct therapy such as AZT, 3-Tc (lamicudine) or protease inhibitors.
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