APOPTOSIS INDUCING PROTEINACEOUS SUBSTANCE

摘要

The invention relates to the field of apoptosis. The invention provides novel therapeutic possibilities, for example novel combinatorial therapies or novel therapeutic compounds that can work alone, sequentially to, or jointly with Apoptin, especially in those cases wherein p53 is (partly) non-functional and/or Bcl-2 is overexpressed and/or functional caspase-3 is lacking. The invention further describes that a proteinaceous substance according to the invention induces apoptosis tumor specific and does not or at least not significantly induce apoptosis in normal cells. The invention comprises an anti-tumor agent, which specifically kill tumor cells and not normal cells.