发明名称 FORMULATION OF SUBSTITUTED BENZIMIDAZOLES
摘要 The present invention relates to stable liquid formulations that comprise a water free or almost water free, polyethylene glycol solution of sodium or potassium salt of a H<+>, K<+>-ATPase inhibitor of formula (I) or a sodium or potassium salt of one single enantiomer thereof. Alternatively, the sodium or potassium salt of the H<+>, K<+>-ATPase inhibitor may be formed <i>in situ</i> in the polyethylene glycol solution by adding sodium or potassium hydroxide together and the active compound. The invention is also directed to the preparation of the claimed formulation, use of the stable liquid formulations in medicine and in the treatment of gastrointestinal diseases.
申请公布号 WO0128558(A1) 申请公布日期 2001.04.26
申请号 WO2000SE01992 申请日期 2000.10.13
申请人 ASTRAZENECA AB;BRUELLS, MIKAEL 发明人 BRUELLS, MIKAEL
分类号 A61K47/34;A61K9/00;A61K9/08;A61K31/4164;A61K31/4184;A61K31/422;A61K31/44;A61K31/4439;A61K47/10;A61K47/30;A61K47/32;A61P1/04;(IPC1-7):A61K31/44 主分类号 A61K47/34
代理机构 代理人
主权项
地址