PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF 5-[2-(4-(BENZOISOTHIAZOL-3-YL)-PIPERAZIN-1-YL)ETHYL]- 6-CHLORO-1,3-DIHYDRO-INDOL-2-ONE

摘要

A process for preparing the compound of formula (I) which comprises treating a compound of formula (II) wherein R2 is hydrogen, CN or CO2R1 and R1 is hydrogen or (C1-C6)alkyl with a reducing agent with th e proviso that when R2 is CN or CO2R1 and R1 is (C1-C6)alkyl the product of the reduction is heated with an acid. Compounds of formula (II) wherein R2 is CN or CO2R1 and R1 is (C1-C6)alkyl or R2 is hydrogen and R1 is (C1-C6)alkyl or hydrogen. The compound of formul a (VII) wherein R1 is (C1-C6)alkyl. The compound of formula (III). The compound of formula (I) is useful in the treatment of psychotic disorders.