发明名称 |
DNA encoding human leukotriene C4 synthase, polypeptides and uses therefor |
摘要 |
An isolated nucleotide sequence encoding human leukotriene C4 synthase or variants of human leukotriene C4 synthase polypeptide, is provided. One embodiment is an isolated DNA sequence (SEQ ID NO.:1) encoding a human leukotriene C4 synthase polypeptide, that has three hydrophobic transmembrane domains. Also described are recombinant cells and plasmids containing the foregoing isolated DNA, preferably linked to a promoter. Isolated leukotriene C4 synthase is provided, having at least three hydrophobic transmembrane domains (SEQ ID NO.:2). Portions of the foregoing isolated human leukotriene C4 synthase polypeptide are also described. Antibodies with selective binding specificity for the polypeptides of the invention also are provided as well as a sensitive method for assay of human leukotriene C4. Methods for producing leukotriene C4 synthase as well as methods for testing for modulators of leukotriene C4 synthase activity are also described.
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申请公布号 |
US6221676(B1) |
申请公布日期 |
2001.04.24 |
申请号 |
US19970986837 |
申请日期 |
1997.12.08 |
申请人 |
BRIGHAM AND WOMEN'S HOSPITAL |
发明人 |
LAM BING K.;PENROSE JOHN F.;AUSTEN K. FRANK |
分类号 |
A61K38/00;C12N9/10;C12N15/54;G01N33/92;(IPC1-7):G01N33/543 |
主分类号 |
A61K38/00 |
代理机构 |
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主权项 |
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地址 |
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