| 摘要 |
Described are new 1-aziridino-1-hydroxyiminomethyl derivatives with the general formula (I), wherein R is able to is a single bond or a linker moiety capable of covalently bonding two aziridine oxime groups, R<SUB>1 </SUB>and R<SUB>2 </SUB>independently of one another are selected from the group consisting of -H, -CH<SUB>3</SUB>, -C<SUB>2</SUB>H<SUB>5</SUB>, -CN, -COOH, -COOCH<SUB>3</SUB>, -COOC<SUB>2</SUB>H<SUB>5</SUB>, -CONH<SUB>2</SUB>, or -C<SUB>6</SUB>H<SUB>5 </SUB>group, and n is the whole number 2, provided that R<SUB>1 </SUB>and R<SUB>2 </SUB>are not both -H and provided that R<SUB>1 </SUB>is not -H if R<SUB>2 </SUB>is -CH<SUB>3 </SUB>and R<SUB>1 </SUB>is not -CH<SUB>3 </SUB>if R<SUB>2 </SUB>is -H The compounds of general formula (I) show antitumor activity. |
