ENANTIO-AND REGIOSELECTIVE SYNTHESES OF ORGANIC COMPOUNDS USING ENOL ESTERS AS IRREVERSIBLE TRANSACYLATION REAGENTS

摘要

A process for irreversible regio- and stereoselective enzyme catalysed acylation of alcohols using enol esters as acylating reagents is disclosed. The present invention permits the selective modification of hydroxyl group(s) of chiral and meso alcohols, including sugars, organometallics, and glycosides. The enol freed upon transesterification rapidly tautomerizea to the corresponding volatile aldehyde or ketone thereby preventing the reverse reaction from occurring.