| 发明名称 |
Hypoxia inducible factor-1 and method of use |
| 摘要 |
The purified and characterization of hypoxia-inducible factor 1 (HIF-1) is described. HIF-1 is composed of subunits HIF-1alpha and HIF-1beta. Purified HIF-1alpha polypeptide, its amino acid sequence and polynucleotide sequence are provided. A HIF-1alpha variant that dimerizes to HIF-1beta producing a nonfunctional HIF-1 complex is described. Methods for the prevention and treatment of hypoxia-related disorders are provided.
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| 申请公布号 |
US6222018(B1) |
申请公布日期 |
2001.04.24 |
| 申请号 |
US19990235217 |
申请日期 |
1999.01.22 |
| 申请人 |
THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE |
发明人 |
SEMENZA GREGG L. |
| 分类号 |
C12N15/09;A61K38/00;A61K48/00;A61P7/00;C07K7/06;C07K7/08;C07K14/47;C07K16/18;C12N5/10;C12N15/12;C12P21/02;G01N33/53;(IPC1-7):C07K16/18 |
主分类号 |
C12N15/09 |
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