| 摘要 |
The present invention relates to a method for enhancing the efficacy of an immune response against an antigen which is a self-antigen. The method of the invention comprises (i) immunization of a host with a mimic of the self-antigen to break tolerance to a self antigen, and (ii) increasing the response to the self-antigen by a booster with the original antigen. An immune response may be generated against any self antigen including, for example, tumor associated antigens, cell surface receptors, receptor ligands, cytokines, hormones, or a self antigen whose expression is associated with a disease or disorder. The method of the invention may be used to target destruction of targeted tumor cells bearing tumor associated antigens in cancer subjects through induction of an immune response. |
