Volume-reducing liquid arrayer and associated methods

摘要

A volume-reducing arrayer apparatus is provided, wherein the arrayer apparatus is adapted to deliver a predetermined amount of a liquid solution from a reservoir to a substrate. The arrayer apparatus generally comprises at least one plate disposed between the reservoir and the substrate and a flow control device disposed between the at least one plate and the substrate and in communication with the at least one plate. The at least one plate is in communication with the reservoir and defines at least one plate capillary extending toward the substrate. The at least one plate capillary is configured to have a reduced volume with respect to the reservoir so as to receive a portion of the solution therefrom. The flow control device is in communication with the at least one plate and defines at least one flow control capillary corresponding to the at least one plate capillary and extending toward the substrate. The at least one flow control capillary is configured to have a reduced volume with respect to the at least one plate capillary. The flow control device is further configured to control the flow of a predetermined amount of the solution through the at least one flow control capillary, from the at least one plate capillary to the substrate. Associated methods of fabricating an arrayer apparatus and delivering biosamples to a biochip are also provided.