CYCLIC ANALOGS OF HISTATINS

摘要

Cyclic analogues of histatin H-5, having from about 7 - 20 amino acid units exhibiting substantial homology to histatin H-5, and having a cyclic portion of from 5 -16 of the amino acid units, have been found to exhibit enhanced bio- activity against a variety of different microorganisms. The cyclic structure is imparted by replacement of naturally occurring amino acids in histatin-5 sequences by, f or example, by cysteine units, so as to cause cyclization through formation of disulfide bridges.