| 摘要 |
organic chemistry, pharmacy. SUBSTANCE: invention relates to novel derivatives of isoxazole of the general formula (I) where R1 means optionally substituted C6-C14-aryl-group or 5-6-membered heterocyclic group having one heteroatom taken among nitrogen, oxygen, sulfur; R2 means hydrogen, halogen atom, optionally substituted C1-C6-alkyl group, C2-C6-alkenyl group, C2-C6-alkynyl group, C3-C10-cycloalkyl group, C3-C10-cycloalkenyl group, cyano-group, carboxyl-group, C1-C7-alkanoyl-group, C2-C7-alkoxycarbonyl-group or optionally substituted carbamoyl-group; R3 means optionally substituted amino-group or saturated 5-6-membered heterocyclic group containing nitrogen atom; X means oxygen or sulfur atom; n means the whole number from 2 to 6, and their pharmaceutically acceptable salts. Invention relates to also pharmaceutical composition showing inhibitory activity with respect to monoaminooxidase type A and containing compound of the formula (I) or its pharmaceutically acceptable salt and pharmaceutically acceptable carrier. EFFECT: new isoxazole derivatives indicated above, valuable biochemical properties. 28 cl, 2 tbl, 107 ex
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