| 摘要 |
organic synthesis. SUBSTANCE: invention improves Chichibabin's amination method, consisting in action of ammonia-containing gas phase at elevated pressures, in that reaction participants are organic solvent, pyridine base, sodium amide, and a reaction-catalyzing organic additive selected from those described by following formulas: formula (I), wherein X is oxygen, imino group or CO2, R1 and R2, independently from each other, are hydrogen or lower alkyl, and n=1-6; formula (II), wherein Y is oxygen or imino group, R3 and R4 are hydrogen atoms, and m and o vary from 1 to 6; formula (III), wherein Z is carbon or sulfur atoms, A oxygen atom, and R5 and R6 lower alkyl or phenyl; formula R7-B, wherein B denotes groups OR8 or NR9R10 (in which R7 is lower alkyl, R8 and R9 hydrogen atoms, and R10 lower alkyl); formula (V), wherein G is hydroxyl or group R11OH (in which R11 denotes lower alkyl); formula (VI), wherein B is amino group and p= 1-3; and formula (VII), wherein B is NO2, OR8, or NR12R13 group (in which R12 and R13 denote lower alkyl or methoxy group), and p=1-3; or this additive can be a cyclic ether, hexamethylphosphoroamide, tetramethylammonium acetate, or hexine. EFFECT: accelerated reaction with the same yield of desired product. 26 cl, 5 tbl, 73 ex |
