NOVEL OPIOIDO-LIKE PEPTIDES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION

摘要

organic chemistry, peptides. SUBSTANCE: invention describes novel opioido-like peptides of the formula (I): X-R1-R2-R3-R4-N(Z)-Y, their salts, derivatives and analogues also where X is hydrogen atom; R1 is Tyr; R2 is D-Ala or D-Arg; R3 is Phe(p-F); R4 is Phe or Phe (p-F); Y and Z mean H. New compounds show analgetic activity of peripheral action and selectivity to subtype of mu-opioid receptors. Invention describes also method of their synthesis and pharmaceutical composition. EFFECT: new peptides indicated above, valuable pharmacological properties. 13 cl, 5 dwg, 1 tbl, 7 ex