PROCESS FOR THE PREPARATION OF PHOSPHOROTHIOATE TRIESTERS AND OLIGONUCLEOTIDES

摘要

A process for the synthesis of a phosphorothioate triester is provided. The process comprises the reaction, in the presence of a coupling agent, of an H-phosphonate with a substrate comprising a free hydroxy group and bonded to a solid support, thereby forming a supported H-phosphonate diester, and subjecting the H-phosphonate diester to sulphur transfer with a sulphur transfer agent.