| 摘要 |
<p>The invention relates to a variety of compositions and methods for inhibiting one or more tumorigenic properties of melanoma cells. The invention also includes methods for identifying compositions which are useful for this purpose and for making pharmaceutical composition from compositions identified in this manner. The invention includes compositions and methods for enhancing expression of E-cadherin expression in melanoma cells and compositions and methods for inhibiting expression of Mel-CAM (MUC18), the β3 subunit of the (αξβ3) vitronectin receptor, or both, in melanoma cells. Other tumorigenic properties of melanoma cells which can be inhibited using the compositions and methods of the invention include melanocyte growth, melanocyte proliferation, melanocyte and invasiveness of melanocytes.</p> |
