Histone acetyl transferase inhibition provides a target for identifying potential antiprotozoal compounds. Histone acetyl transferase inhibitors are useful as therapeutic agents against protozoal infections. A method of identifying histone acetyl transferase inhibitors compares i) the acetylation level from a combination of a test compound with a known histone deacetylase inhibitor to ii) a basal acetylation level.
申请公布号
WO0127314(A1)
申请公布日期
2001.04.19
申请号
WO2000US27337
申请日期
2000.10.04
申请人
MERCK & CO., INC.;SCHMATZ, DENNIS, M.;GURNETT, ANNE, M.;SAMARAS, SAMANTHA, D.
发明人
SCHMATZ, DENNIS, M.;GURNETT, ANNE, M.;SAMARAS, SAMANTHA, D.