| 发明名称 |
CRYSTALLOGRAPHIC STRUCTURE OF THE ANDROGEN RECEPTOR LIGAND BINDING DOMAIN |
| 摘要 |
The first crystal structure of the androgen receptor ligand binding domain h as been determined to 2.0 angstrom resolution. Disclosed are the coordinates fo r the crystal structure, and methods for determining agonists, partial agonist s, antagonists, partial antagonists, and selective androgen receptors modulator s (SARMS) of the androgen receptor.
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| 申请公布号 |
CA2388253(A1) |
申请公布日期 |
2001.04.19 |
| 申请号 |
CA20002388253 |
申请日期 |
2000.10.13 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
EINSPAHR, HOWARD M.;WEINMANN, ROBERTO;ATTAR, RICARDO M.;WANG, CHIHUEI;SALVATI, MARK E.;TOKARSKI, JOHN S.;KRYSTEK, STANLEY R., JR.;SACK, JOHN S. |
| 分类号 |
G01N33/50;A61K38/22;A61K45/00;A61P15/10;A61P19/10;A61P21/00;A61P35/00;A61P43/00;C07J1/00;C07K1/00;C07K14/72;C12N15/09;G01N31/00;G01N33/15;G01N33/48;G01N33/53;G01N33/566;G01N33/74;G06F19/00;(IPC1-7):G01N33/53 |
主分类号 |
G01N33/50 |
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