| 摘要 |
<p>Compounds of formula (I) and (II) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections wherein R1 is H or C¿1-4?alkyl; R?2¿ is C¿1-4?alkyl; R?3¿ is (a) or (b); Q is a single bond, -O-, -S-, -NH-, -CH¿2?-, or -CH2CH2-; R?4¿ is C¿1-6?alkyl, OC1-6alkyl, OH, CF3 or piperidinyl; (c) is a five- or six-membered heteroaromatic ring or a six-membered aromatic ring unsubstituted or substituted by R?5¿; (d) is a five- or six-membered heteroaromatic ring or a six-membered aromatic ring unsubstituted or substituted by R6; (e) is a five- or six-membered heteroaromatic ring or a six-membered aromatic ring unsubstituted or substituted by R6; R5 is OR' or NR'C(O)R'; R6 is OR' or N(R')¿2?; X is H, C1-4alkyl, OR', SR', CN, N(R')2, CH2N(R')2, NO2, CF3, CO2R', CON(R')2, COR', NR'C(O)R', F, Cl, Br, I or -S(O)rCF3; R' is H, C1-6alkyl or -C0-6alkyl-Ar; and r is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.</p> |
