NOVEL CELLS AND MOLECULES INVOLVED IN IMMUNE REGULATION

摘要

Novel cells and molecules involved in immune regulation are disclosed. The novel cells are regulatory T cells having the phenotype CD<3>+ alpha beta TCR<+>CD4<->CD8<->CD44<->CD28<->NK1<.>1-. The regulatory cells express high levels of Ly-6A and osteopontin while non-regulatory cells do not. Inhibiting Ly-6A or osteopontin inhibits the suppressive properties of the cells.