<p>Modified anti-angiogenic peptides are disclosed. The modified peptides are capable of forming a peptidase stabilized anti-angiogenic peptide. The modified anti-angiogenic peptides, particularly modified kringle 5 peptides are capable of forming a conjugate with a blood protein. Conjugates are prepared from anti-angiogenic peptides, particularly kringle 5 peptides, by combining the peptide with a reactive functional group with a blood protein. The conjugates may be formed <i>in vivo</i> or <i>ex vivo</i>. The conjugates are administered to patients to provide an anti-angiogenic effect.</p>
申请公布号
WO0070665(A3)
申请公布日期
2001.04.19
申请号
WO2000IB00763
申请日期
2000.05.17
申请人
CONJUCHEM, INC.;BRIDON, DOMINIQUE, P.;RASAMOELISOLO, MICHELE;THIBAUDEAU, KAREN;HUANG, XICAI;BELIVEAU, RICHARD
发明人
BRIDON, DOMINIQUE, P.;RASAMOELISOLO, MICHELE;THIBAUDEAU, KAREN;HUANG, XICAI;BELIVEAU, RICHARD