发明名称 |
MEDIATORS OF HEDGEHOG SIGNALLING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO |
摘要 |
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of - function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
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申请公布号 |
CA2388468(A1) |
申请公布日期 |
2001.04.19 |
申请号 |
CA20002388468 |
申请日期 |
2000.10.13 |
申请人 |
CURIS, INC. |
发明人 |
GUICHERIT, OIVIN M.;PRICE, STEPHEN;RUBIN, LEE;BAXTER, ANTHONY DAVID;BOYD, EDWARD ANDREW |
分类号 |
C07D403/14;A61K31/40;A61K31/4025;A61K31/496;A61P1/16;A61P11/00;A61P15/00;A61P17/00;A61P17/14;A61P19/08;A61P21/00;A61P35/00;A61P43/00;C07D207/14;C07D405/06;C07D409/06;(IPC1-7):A61K31/40;A61K31/495 |
主分类号 |
C07D403/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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