| 发明名称 |
NEUTRAL-CATIONIC LIPID FOR NUCLEIC ACID AND DRUG DELIVERY |
| 摘要 |
A lipid represented by formula (I), wherein each of R1 and R2 is an alkyl or alkenyl chain having between about 8 to about 24 carbon atoms; n = 1-20; L i s selected from the group consisting of (i) -X-(C=O)-Y-CH2-, (ii) -X-(C=O)-, a nd (iii) -X-CH2-, wherein X and Y are independently selected from oxygen, NH an d a direct bond; and Z is a weakly basic moiety that has a pK of less than abo ut 7.4 and greater than about 4.0 is described. |
| 申请公布号 |
CA2386164(A1) |
申请公布日期 |
2001.04.19 |
| 申请号 |
CA20002386164 |
申请日期 |
2000.10.10 |
| 申请人 |
ALZA CORPORATION |
发明人 |
HUANG, SHI KUN;ZALIPSKY, SAMUEL;ZHANG, WEI-MING;JIN, BEI;QUINN, YOLANDA P. |
| 分类号 |
C07D233/02;A61K9/127;A61K31/7105;A61K31/711;A61K47/22;A61K47/44;A61K48/00;A61P35/00;A61P43/00;C07D233/54;(IPC1-7):C07D233/54;C07C271/28;C07H5/06;A61K47/00 |
主分类号 |
C07D233/02 |
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