The invention relates to methods of predicting mutations that alter the activity of a receptor in a desired manner. The methods utilize multiple sequence alignment and phylogenetic profiling to identify the relatives of a given receptor that are most likely to provide useful data allowing prediction of sites to mutate in the given receptor. The methods provided are applicable to any type of receptor, and are particularly well suited for predicting sites to mutate in order to alter the activities of the so-called orphan receptors, for which no agonists are known.
申请公布号
WO0127632(A2)
申请公布日期
2001.04.19
申请号
WO2000IB01407
申请日期
2000.10.02
申请人
CAMBRIDGE DRUG DISCOVERY, LTD.;WILLIAMS, KATHLEEN, M.;WENHAM, DEAN;PACKER, JEREMY, CHARLES